Herpes simplex virus (HSV)

Herpes simplex virus (HSV) infections are common and can cause painful blisters or ulcers. The infection is caused by two related types of the virus: HSV-1, which most often causes oral herpes (cold sores), and HSV-2, which is the most frequent cause of genital herpes. Both types can infect either the mouth or genital area and are spread through direct contact. Once infected, the virus stays in the body for life, hiding in nerve cells and periodically reactivating, which can cause outbreaks.

Common causes and triggers

An HSV infection is primarily acquired through skin-to-skin contact, even when no sores are visible.

  • HSV-1 is commonly spread through oral contact, such as kissing or sharing utensils, and most people get it in childhood in daycare as they share cups.

  • HSV-2 is primarily transmitted through sexual contact with an infected partner, even if they don't have visible sores.

  • Triggers for reactivation of the dormant virus, leading to an outbreak, can include:

    • Stress or fatigue

    • Illness or fever

    • Menstruation

    • Sun exposure or sunburn

    • A weakened immune system

    • Surgery or injury

Signs and symptoms

Many people with HSV have no symptoms at all or very mild ones they mistake for other skin conditions, such as a pimple or ingrown hair. When symptoms do appear, they can vary depending on whether it's the first outbreak or a recurrent one.

Initial Outbreak (often more severe):

  • Flu-like symptoms, including fever, body aches, headaches, and swollen lymph nodes

  • Tingling, itching, or burning where the sores will appear

  • Clusters of small, fluid-filled blisters that break open, ooze, and crust over

  • Painful sores that can take two to four weeks to heal

Recurrent Outbreaks (usually less severe and shorter):

  • Often preceded by a tingling, itching, or painful sensation (called a prodrome)

  • Sores typically appear in the same area as the initial outbreak

  • Heal more quickly, usually within 5 to 10 days

  • Frequency and severity often decrease over time

Diagnosis

Healthcare providers can diagnose herpes through a physical exam and various tests.

  • Viral culture or PCR test: If active sores or blisters are present, a doctor can swab the area to collect a sample of the fluid. This sample can then be tested to confirm the presence of HSV and determine the specific type (HSV-1 or HSV-2). PCR tests are generally more sensitive than viral cultures.

  • Blood test: If there are no active sores, a blood test can detect antibodies produced by the immune system in response to an HSV infection. A positive result indicates past exposure to the virus but cannot determine the location or timing of the infection.

  • Important note: The Centers for Disease Control and Prevention (CDC) does not recommend routine screening for herpes in the general population.

Treatment

While there is no cure for HSV, antiviral medications can effectively manage symptoms, shorten the duration of outbreaks, and reduce the frequency of recurrences.

During an outbreak:

  • Antiviral medication: Your doctor can prescribe oral antiviral drugs like acyclovir, valacyclovir, or famciclovir. These are most effective when started within 48 hours of symptoms beginning.

  • Pain relief: Over-the-counter pain medications like ibuprofen can help with pain. For oral herpes, numbing gels can also offer temporary relief.

  • Soothing measures: For genital herpes, a warm bath or wearing loose-fitting clothing can help alleviate discomfort.

To prevent future outbreaks (suppressive therapy):

  • Daily antiviral medication: For individuals with frequent or severe outbreaks, taking a daily antiviral medication can suppress the virus, significantly reducing the number of outbreaks.

  • Viral shedding reduction: Daily suppressive therapy also lowers the risk of spreading the virus to sexual partners.

What to do to prevent spreading:

  • Avoid skin-to-skin contact with the infected area during an outbreak.

  • Use condoms during sexual activity. This reduces the risk but does not eliminate it, as the virus can be on areas not covered by a condom.

  • Communicate with your sexual partner(s) about the infection.


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